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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM340782
Substrate
n/a
Meas. Tech.
IDO Kynurenine Assay
IC50
5.92±n/a nM
Citation
 Markwalder, JA; Seitz, SP; Balog, JA; Huang, A; Mandal, SK; Williams, DK; Hart, AC; Inghrim, J IDO inhibitors US Patent  US9765018 Publication Date 9/19/2017 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM340782
Synonyms:
1-(5-Butyl-4-propoxy-2′-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl)-3-(p-tolyl)urea | US9765018, Example 22
Type:
Small organic molecule
Emp. Form.:
C28H32N6O2
Mol. Mass.:
484.5927
SMILES:
CCCCc1cc(cc(NC(=O)Nc2ccc(C)cc2)c1OCCC)-c1ccccc1-c1nnn[nH]1
Structure:
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