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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM340784
Substrate
n/a
Meas. Tech.
IDO Kynurenine Assay
IC50
20.0±n/a nM
Citation
 Markwalder, JA; Seitz, SP; Balog, JA; Huang, A; Mandal, SK; Williams, DK; Hart, AC; Inghrim, J IDO inhibitors US Patent  US9765018 Publication Date 9/19/2017 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM340784
Synonyms:
(E)-1-(5-(4,4-Difluorobuta-1,3-dien-1-yl)-4-propoxy-2′-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl)-3-(p-tolyl)urea | US9765018, Example 30
Type:
Small organic molecule
Emp. Form.:
C28H26F2N6O2
Mol. Mass.:
516.5418
SMILES:
CCCOc1c(NC(=O)Nc2ccc(C)cc2)cc(cc1\C=C\C=C(F)F)-c1ccccc1-c1nnn[nH]1 |(4.67,1.15,;3.33,.38,;2,1.15,;.67,.38,;-.67,1.15,;-.67,2.69,;.67,3.46,;.67,5,;-.67,5.77,;2,5.77,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;7.34,2.69,;6,5,;4.67,5.77,;-2,3.46,;-3.33,2.69,;-3.33,1.15,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;.67,-4.24,;.67,-5.77,;2,-3.47,;-4.67,3.46,;-4.67,5,;-6,5.77,;-7.34,5,;-7.34,3.46,;-6,2.69,;-6,1.15,;-4.76,.25,;-5.23,-1.21,;-6.77,-1.21,;-7.25,.25,)|
Structure:
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