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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM340809
Substrate
n/a
Meas. Tech.
IDO Kynurenine Assay
IC50
70.0±n/a nM
Citation
 Markwalder, JA; Seitz, SP; Balog, JA; Huang, A; Mandal, SK; Williams, DK; Hart, AC; Inghrim, J IDO inhibitors US Patent  US9765018 Publication Date 9/19/2017 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM340809
Synonyms:
3'-(3-(2-chlorophenyl) ureido)-4-methoxy-4'-(2- methyl-3-(prop-2- ynyloxy)phenoxy) biphenyl-3-carboxylic acid | US9765018, Example 136
Type:
Small organic molecule
Emp. Form.:
C31H25ClN2O6
Mol. Mass.:
556.993
SMILES:
COc1ccc(cc1C(O)=O)-c1ccc(Oc2cccc(OCC#C)c2C)c(NC(=O)Nc2ccccc2Cl)c1
Structure:
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