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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM340831
Substrate
n/a
Meas. Tech.
IDO Kynurenine Assay
IC50
1620±n/a nM
Citation
 Markwalder, JA; Seitz, SP; Balog, JA; Huang, A; Mandal, SK; Williams, DK; Hart, AC; Inghrim, J IDO inhibitors US Patent  US9765018 Publication Date 9/19/2017 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM340831
Synonyms:
4'-(2-tert- butylphenoxy)-5- fluoro-3'-(3-o- tolylureido) biphenyl-3- carboxylic acid | US9765018, Example 254
Type:
Small organic molecule
Emp. Form.:
C31H29FN2O4
Mol. Mass.:
512.5714
SMILES:
Cc1ccccc1NC(=O)Nc1cc(ccc1Oc1ccccc1C(C)(C)C)-c1cc(F)cc(c1)C(O)=O
Structure:
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