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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM341638
Substrate
n/a
Meas. Tech.
Biochemical In Vitro Assay
IC50
3.00±n/a nM
Citation
 Bur, D; Grisostomi, C; Nayler, O; Remen, L; Vercauteren, M; Welford, R Tricyclic piperidine compounds US Patent  US9765092 Publication Date 9/19/2017 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM341638
Synonyms:
N-(6-chloro-5-(2-(5-(4-chloro-2-fluorophenyl)-7,8-dihydrothiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-oxoethoxy)pyridin-2-yl)methanesulfonamide | US9765092, Example 6.4.8
Type:
Small organic molecule
Emp. Form.:
C22H18Cl2FN5O4S2
Mol. Mass.:
570.444
SMILES:
CS(=O)(=O)Nc1ccc(OCC(=O)N2CCc3nc4sccn4c3C2c2ccc(Cl)cc2F)c(Cl)n1
Structure:
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