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Target
Proto-oncogene tyrosine-protein kinase Src [145-252]
Ligand
BDBM14692
Substrate
Peptide Substrate
Meas. Tech.
Scintillation Proximity Assay (SPA)
IC50
10±n/a nM
Citation
 Lange, G; Lesuisse, D; Deprez, P; Schoot, B; Loenze, P; Benard, D; Marquette, JP; Broto, P; Sarubbi, E; Mandine, E Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J Med Chem 46:5184-95 (2003) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [145-252]
Synonyms:
Proto-oncogene tyrosine-protein kinase Src | Proto-oncogene tyrosine-protein kinase Src (aa 145-252) | SRC | SRC1 | SRC_HUMAN | c-Src pp60c-src | p60-Src
Type:
SH2 Domain
Mol. Mass.:
12362.36
Organism:
Homo sapiens (Human)
Description:
Src-SH2 proteins (amino acid residues 145-252) were chemically biotinylated using a 10-fold molar excess of D-biotin-N-hydroxy-succinimidester and purified by gel filtration yielding conjugates with an average ratio of two biotin moieties per protein molecule.
Residue:
108
Sequence:
SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSK
  
Inhibitor
Name:
BDBM14692
Synonyms:
2-{4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]carbamoyl}ethyl]-2-(methoxycarbonyl)phenyl}-2-fluoropropanedioic acid | RU90395 | inhibitor 4 | {4-[(2S)-2-(acetylamino)-3-{[(3S)-1-(biphenyl-4-ylmethyl)-2-oxoazepan-3-yl]amino}-3-oxopropyl]-2-(methoxycarbonyl)phenyl}(fluoro)propanedioic acid
Type:
Small organic molecule
Emp. Form.:
C35H36FN3O9
Mol. Mass.:
661.6734
SMILES:
COC(=O)c1cc(C[C@H](NC(C)=O)C(=O)N[C@H]2CCCCN(Cc3ccc(cc3)-c3ccccc3)C2=O)ccc1C(F)(C(O)=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1600.79
Organism:
n/a
Description:
Peptide EPQpYEEIPIYL (middle-T antigen) was monoiodinated on tyrosine.
Residue:
13
Sequence:
IEPQPYEEIPIYL