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Target
Malignant T-cell-amplified sequence 1
Ligand
BDBM345283
Substrate
n/a
Meas. Tech.
Assay 4: MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells
IC50
16000±n/a nM
Citation
 Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent  US10202350 Publication Date 2/12/2019 
Target
Name:
Malignant T-cell-amplified sequence 1
Synonyms:
MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20563.62
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
181
Sequence:
MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
  
Inhibitor
Name:
BDBM345283
Synonyms:
2-[[1-[(2-Bromophenyl)methyl]-5-(3- isopropoxyphenyl)pyrazol-3-yl]methoxy]- 2-methyl-propanoic acid. 1HNMR (CDCl3): $#948; 1.21 (s, 3H), 1.23 (s, 3H), 4.28-4.32 (m, 1H), 4.62 (s, 2H), 5.39 (s, 2H).6.42 (s, 1H), 6.71-6.74 (m, 2H), 6.82- 6.89 (m, 2H), 7.11-7.15 (m, 1H), 7.22- 7.27 (m, 2H), 7.51-7.54 (m, 1H). | US10202350, Example 29 | US10214492, Example 29 | US11292767, Example 29 | US11724989, Example 29
Type:
Small organic molecule
Emp. Form.:
C24H27BrN2O4
Mol. Mass.:
487.386
SMILES:
CC(C)Oc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Br
Structure:
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