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Target
Malignant T-cell-amplified sequence 1
Ligand
BDBM345300
Substrate
n/a
Meas. Tech.
Assay 4: MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells
IC50
47000±n/a nM
Citation
 Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent  US10202350 Publication Date 2/12/2019 
Target
Name:
Malignant T-cell-amplified sequence 1
Synonyms:
MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20563.62
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
181
Sequence:
MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
  
Inhibitor
Name:
BDBM345300
Synonyms:
2-[[1-[(2-Chlorophenyl)methyl]-5-(3- morpholinophenyl)pyrazol-3-yl]methoxy]- 2-methyl-propanoic acid. 1HNMR (CDCl3): $#948; 1.55 (s, 6H), 2.96 (t, 4H), 3.76 (t, 4H), 4.62 (s, 2H), 5.41 (s, 2H), 6.41 (s, 1H), 6.68 (s, 1H), 6.78-6.80 (m, 2H), 6.88-6.91 (m, 1H), 7.19-7.35 (m, 4H). | US10202350, Example 46 | US10214492, Example 46 | US11292767, Example 46 | US11724989, Example 46
Type:
Small organic molecule
Emp. Form.:
C25H28ClN3O4
Mol. Mass.:
469.961
SMILES:
CC(C)(OCc1cc(-c2cccc(c2)N2CCOCC2)n(Cc2ccccc2Cl)n1)C(O)=O
Structure:
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