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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM50178220
Substrate
n/a
Meas. Tech.
BRD4 AlphaLisa Binding Assay
IC50
4028±n/a nM
Citation
 Romero, FA; Magnuson, SR; Pastor, R; Tsui, VH; Murray, J; Crawford, T; Burdick, DJ; Albrecht, BK; Cote, A; Taylor, AM; Nasveschuck, CG; LeBlanc, Y; Hewitt, MC; Lai, KW; Chen, K Therapeutic compounds and uses thereof US Patent  US10206931 Publication Date 2/19/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM50178220
Synonyms:
CHEMBL3814550 | US10206931, Example 57
Type:
Small organic molecule
Emp. Form.:
C21H22N4O
Mol. Mass.:
346.4256
SMILES:
C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C5CC5)c4c3)c2N1 |r|
Structure:
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