Reaction Details Report a problem with these data
Target
Atypical chemokine receptor 3
Ligand
BDBM345977
Substrate
n/a
Meas. Tech.
In Vitro Assay
EC50
1.000±n/a nM
Citation
 Guerry, P; Lehembre, F; Pothier, J; Siendt, H CXCR7 receptor modulators US Patent  US10202368 Publication Date 2/12/2019 
Target
Name:
Atypical chemokine receptor 3
Synonyms:
ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1
Type:
Enzyme
Mol. Mass.:
41498.84
Organism:
Homo sapiens (Human)
Description:
P25106
Residue:
362
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
  
Inhibitor
Name:
BDBM345977
Synonyms:
2-(4-Cyclopropylmethyl-1-methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylamino)-N-(2-isopropylamino-ethyl)-N-(2-trifluoromethyl-benzyl)-acetamide | US10202368, Example 52
Type:
Small organic molecule
Emp. Form.:
C29H40F3N5O
Mol. Mass.:
531.656
SMILES:
CC(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)CCN(C)c12
Structure:
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