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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM65518
Substrate
n/a
Meas. Tech.
Fluorometric Ub-AMC Hydrolysis Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
2500±n/a nM
Comments
extracted
Citation
 Ott, CA; Baljinnyam, B; Zakharov, AV; Jadhav, A; Simeonov, A; Zhuang, Z Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors. ACS Chem Biol 12:2399-2407 (2017) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM65518
Synonyms:
5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) | 668467-91-2 | LDN-57444
Type:
Small organic molecule
Emp. Form.:
C17H11Cl3N2O3
Mol. Mass.:
397.64
SMILES:
CC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Cl)cc12 |w:4.3|
Structure:
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