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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM347359
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
2.56±n/a nM
Citation
 Markowitz, S; Willson, JK; Posner, B; Ready, J; Antczak, M; Zhang, Y; Desai, A; Gerson, S; Greenlee, W Compositions and methods of modulating short-chain dehydrogenase activity US Patent  US9789116 Publication Date 10/17/2017 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | Hpgd | PGDH_MOUSE | Pgdh1 | Prostaglandin dehydrogenase 1 (15-PGDH)
Type:
Protein
Mol. Mass.:
29180.48
Organism:
Mus musculus (Mouse)
Description:
Q8VCC1
Residue:
269
Sequence:
MHVNGKVALVTGAAQGIGKAFAEALLLHGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFVQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVDTPILESIEKEENMGQYIEYKDQIKAMMKFYGVLHPSTIANGLINLIEDDALNGAIMKITASKGIHFQDYDISPLLVKAPLTS
  
Inhibitor
Name:
BDBM347359
Synonyms:
US10301320, ID SW033291 | US10869871, ID # SW033291 | US20230285402, ID # SW206976 | US9789116, SW033291
Type:
Small organic molecule
Emp. Form.:
C21H20N2OS3
Mol. Mass.:
412.591
SMILES:
CCCCS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Structure:
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