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Target
Interleukin-1 receptor-associated kinase 1 [194-712]
Ligand
BDBM348060
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<100±n/a nM
Citation
 Jorand-Lebrun, C; Jones, R; Won, AC; Nguyen, N; Johnson, TL; Deselm, LC; Panda, K Heteroaryl compounds as IRAK inhibitors and uses thereof US Patent  US9790221 Publication Date 10/17/2017 
Target
Name:
Interleukin-1 receptor-associated kinase 1 [194-712]
Synonyms:
IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55943.99
Organism:
Homo sapiens (Human)
Description:
aa 194-712
Residue:
519
Sequence:
RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
  
Inhibitor
Name:
BDBM348060
Synonyms:
US9790221, Compound 268
Type:
Small organic molecule
Emp. Form.:
C24H27N7O2
Mol. Mass.:
445.5169
SMILES:
Cn1cc(cn1)-c1cccc(c1)-c1ncc(-c2cnn(C)c2)c(N[C@H]2CCC[C@@H](O)[C@H]2O)n1 |r|
Structure:
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