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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Ligand
BDBM13951
Substrate
BDBM13466
Meas. Tech.
PTP1B and TCPTP Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
93000±n/a nM
Citation
 Xin, Z; Oost, TK; Abad-Zapatero, C; Hajduk, PJ; Pei, Z; Szczepankiewicz, BG; Hutchins, CW; Ballaron, SJ; Stashko, MA; Lubben, T; Trevillyan, JM; Jirousek, MR; Liu, G Potent, selective inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett 13:1887-90 (2003) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Synonyms:
PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1
Type:
Enzyme
Mol. Mass.:
34670.65
Organism:
Homo sapiens (Human)
Description:
The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli.
Residue:
298
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
  
Inhibitor
Name:
BDBM13951
Synonyms:
2-[(2,3-Dimethylphenyl)oxalylamino]benzoic acid | 2-[(2,3-dimethylphenyl)amidoformic acid]benzoic acid | CHEMBL65459 | diaryloxamic acid 1 | oxalyl-aryl-amino benzoic acid-based inhibitor 1
Type:
Small organic molecule
Emp. Form.:
C17H15NO5
Mol. Mass.:
313.3047
SMILES:
Cc1cccc(N(C(=O)C(O)=O)c2ccccc2C(O)=O)c1C
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM13466
Synonyms:
4-Nitrophenyl phosphate disodium salt hexahydrate | 4-nitrophenyl phosphate (pNPP) | disodium (4-nitrophenyl) phosphate | para-nitrophenyl phosphate (pNPP)
Type:
Small organic molecule
Emp. Form.:
C6H4NO6P
Mol. Mass.:
217.0739
SMILES:
[O-][N+](=O)c1ccc(O[P+]([O-])([O-])[O-])cc1
Structure:
Search PDB for entries with ligand similarity: