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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM15808
Substrate
BDBM13466
Meas. Tech.
PTP1B and TCPTP Inhibition Assay
Ki
3600±n/a nM
Citation
 Xin, Z; Oost, TK; Abad-Zapatero, C; Hajduk, PJ; Pei, Z; Szczepankiewicz, BG; Hutchins, CW; Ballaron, SJ; Stashko, MA; Lubben, T; Trevillyan, JM; Jirousek, MR; Liu, G Potent, selective inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett 13:1887-90 (2003) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM15808
Synonyms:
1:1 racemic mixture | 2-{[4-(2-acetamido-2-{[(4-methoxyphenyl)methyl]carbamoyl}ethyl)-2-ethylphenyl]amidoformic acid}benzoic acid | oxalyl-aryl-amino benzoic acid-based inhibitor 8c
Type:
Small organic molecule
Emp. Form.:
C30H31N3O8
Mol. Mass.:
561.5824
SMILES:
CCc1cc(CC(NC(C)=O)C(=O)NCc2ccc(OC)cc2)ccc1N(C(=O)C(O)=O)c1ccccc1C(O)=O
Structure:
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Substrate
Name:
BDBM13466
Synonyms:
4-Nitrophenyl phosphate disodium salt hexahydrate | 4-nitrophenyl phosphate (pNPP) | disodium (4-nitrophenyl) phosphate | para-nitrophenyl phosphate (pNPP)
Type:
Small organic molecule
Emp. Form.:
C6H4NO6P
Mol. Mass.:
217.0739
SMILES:
[O-][N+](=O)c1ccc(O[P+]([O-])([O-])[O-])cc1
Structure:
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