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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM615625
Substrate
n/a
Meas. Tech.
Tag-Lite Binding Assay
Ki
29.3±n/a nM
Citation
 Liang, B; Yang, Y; Wang, P; Yang, B; Lai, Y; Wu, JJ GLP-1R MODULATING COMPOUNDS US Patent  US20230271949 Publication Date 8/31/2023 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM615625
Synonyms:
US20230271949, Example 416
Type:
Small organic molecule
Emp. Form.:
C40H32ClF3N6O4
Mol. Mass.:
753.168
SMILES:
Cc1n[nH]c2c(F)cc(cc12)C(=O)Nc1ccc2n(C[C@@H]3CCO3)c(Cc3cc(F)c(cc3CO)-c3cccc(OCc4ccc(Cl)cc4F)n3)nc2c1 |r|
Structure:
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