Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Mer
Ligand
BDBM350839
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<250±n/a nM
Citation
 Wang, X; Liu, J; Zhang, W; Frye, S; Kireev, D Pyrrolopyrimidine compounds for the treatment of cancer US Patent  US9795606 Publication Date 10/24/2017 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM350839
Synonyms:
UNC1534A | US9795606, A3
Type:
Small organic molecule
Emp. Form.:
C28H41N7O2S
Mol. Mass.:
539.736
SMILES:
CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1 |r,wU:13.12,wD:16.16,(-9.17,-3.77,;-7.84,-3,;-6.5,-3.77,;-5.17,-3,;-3.84,-3.77,;-2.5,-3,;-2.5,-1.46,;-1.17,-.69,;.16,-1.46,;1.63,-.99,;2.53,-2.23,;1.63,-3.48,;2.03,-4.96,;3.51,-5.36,;4.6,-4.27,;6.09,-4.67,;6.49,-6.16,;7.98,-6.56,;5.4,-7.25,;3.91,-6.85,;.16,-3,;-1.17,-3.77,;2.03,.5,;3.51,.9,;3.91,2.39,;2.82,3.48,;1.34,3.08,;.94,1.59,;3.22,4.96,;1.68,4.96,;3.22,6.5,;4.71,5.36,;5.8,4.27,;7.29,4.67,;7.68,6.16,;9.17,6.56,;6.6,7.25,;5.11,6.85,)|
Structure:
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