Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Mer
Ligand
BDBM350840
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<250±n/a nM
Citation
 Wang, X; Liu, J; Zhang, W; Frye, S; Kireev, D Pyrrolopyrimidine compounds for the treatment of cancer US Patent  US9795606 Publication Date 10/24/2017 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM350840
Synonyms:
UNC1535A | US9795606, A4
Type:
Small organic molecule
Emp. Form.:
C23H32N6O2S
Mol. Mass.:
456.604
SMILES:
CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(N)(=O)=O |r,wU:13.12,wD:16.16,(-8.57,-3.4,;-7.24,-2.63,;-5.91,-3.4,;-4.57,-2.63,;-3.24,-3.4,;-1.91,-2.63,;-1.91,-1.09,;-.57,-.32,;.76,-1.09,;2.23,-.61,;3.13,-1.86,;2.23,-3.1,;2.62,-4.59,;4.11,-4.99,;5.2,-3.9,;6.69,-4.3,;7.09,-5.79,;8.57,-6.19,;6,-6.88,;4.51,-6.48,;.76,-2.63,;-.57,-3.4,;2.62,.87,;4.11,1.27,;4.51,2.76,;3.42,3.85,;1.93,3.45,;1.54,1.96,;3.82,5.34,;5.31,5.74,;2.28,5.34,;3.82,6.88,)|
Structure:
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