Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Mer
Ligand
BDBM350856
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<250±n/a nM
Citation
 Wang, X; Liu, J; Zhang, W; Frye, S; Kireev, D Pyrrolopyrimidine compounds for the treatment of cancer US Patent  US9795606 Publication Date 10/24/2017 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM350856
Synonyms:
UNC2146A | US10004755, Compound UNC2146A | US9795606, B15
Type:
Small organic molecule
Emp. Form.:
C25H31F2N5O3S
Mol. Mass.:
519.607
SMILES:
CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CC(F)(F)C1 |r,wU:11.11,wD:15.15,(-8.74,-2.57,;-7.4,-1.8,;-6.07,-2.57,;-4.74,-1.8,;-3.4,-2.57,;-2.07,-1.8,;-2.07,-.26,;-.73,.51,;.6,-.26,;2.06,.22,;2.97,-1.03,;2.06,-2.27,;2.46,-3.76,;3.95,-4.16,;4.35,-5.65,;3.26,-6.73,;3.66,-8.22,;1.77,-6.34,;1.37,-4.85,;.6,-1.8,;-.73,-2.57,;2.46,1.71,;3.95,2.11,;4.35,3.59,;3.26,4.68,;1.77,4.28,;1.37,2.8,;3.66,6.17,;2.12,6.17,;2.89,7.5,;5.15,6.57,;6.48,5.8,;7.25,7.13,;8.34,8.22,;8.74,6.73,;5.92,7.9,)|
Structure:
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