Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Mer
Ligand
BDBM350862
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<250±n/a nM
Citation
 Wang, X; Liu, J; Zhang, W; Frye, S; Kireev, D Pyrrolopyrimidine compounds for the treatment of cancer US Patent  US9795606 Publication Date 10/24/2017 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM350862
Synonyms:
UNC1651A | US9795606, B23
Type:
Small organic molecule
Emp. Form.:
C28H36F4N6O3S
Mol. Mass.:
612.682
SMILES:
CC(C)(C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1 |r,wU:12.11,wD:15.15,(-11.12,-1.16,;-9.79,-.39,;-9.79,1.15,;-9.79,-1.93,;-8.45,-1.16,;-7.12,-.39,;-7.12,1.15,;-5.79,1.92,;-4.45,1.15,;-2.99,1.63,;-2.08,.38,;-2.99,-.86,;-2.59,-2.35,;-1.1,-2.75,;-.7,-4.24,;-1.79,-5.33,;-1.39,-6.81,;-3.28,-4.93,;-3.68,-3.44,;-4.45,-.39,;-5.79,-1.16,;-2.22,2.96,;-.88,2.19,;.45,2.96,;.45,4.5,;-.88,5.27,;-.88,6.81,;-2.22,4.5,;1.78,5.27,;1.01,6.61,;2.55,6.61,;3.12,4.5,;3.12,2.96,;4.44,2.13,;5.84,2.94,;7.17,2.17,;8.51,2.94,;9.84,3.71,;9.28,1.61,;7.74,4.27,;5.83,4.55,;4.45,5.27,)|
Structure:
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