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Target
RAC-beta serine/threonine-protein kinase
Ligand
BDBM16232
Substrate
AKTide-2T
Meas. Tech.
PKB In Vitro Enzyme Assay
pH
7.2±n/a
Temperature
295.15±n/a K
IC50
20±3 nM
Citation
 Donald, A; McHardy, T; Rowlands, MG; Hunter, LJ; Davies, TG; Berdini, V; Boyle, RG; Aherne, GW; Garrett, MD; Collins, I Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design. J Med Chem 50:2289-92 (2007) [PubMed]  Article 
Target
Name:
RAC-beta serine/threonine-protein kinase
Synonyms:
AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:
Enzyme
Mol. Mass.:
55766.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
  
Inhibitor
Name:
BDBM16232
Synonyms:
6-phenylpurine compound 20 | 6-{4-[4-(4-chlorophenyl)piperidin-4-yl]phenyl}-9H-purine
Type:
Small organic molecule
Emp. Form.:
C22H20ClN5
Mol. Mass.:
389.881
SMILES:
Clc1ccc(cc1)C1(CCNCC1)c1ccc(cc1)-c1ncnc2nc[nH]c12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
AKTide-2T
Synonyms:
AKT/PKB/Rac Protein Kinase Substrate
Type:
Peptide
Mol. Mass.:
1719.90
Organism:
n/a
Description:
n/a
Residue:
14
Sequence:
ARKRERTYSFGHHA