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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM352237
Substrate
n/a
Meas. Tech.
Radiolabel Binding Assay
IC50
78.0±n/a nM
Citation
 Canney, DJ; Blass, BE; Gao, R; Abou-Gharbia, M 5-hydroxytryptamine receptor 7 activity modulators and their method of use US Patent  US9802924 Publication Date 10/31/2017 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM352237
Synonyms:
US10239868, Entry 38 | US10287274, Entry 38 | US10676464, Entry 38 | US9802924, Entry 38
Type:
Small organic molecule
Emp. Form.:
C28H35NO2
Mol. Mass.:
417.583
SMILES:
[#6]-[#6]C1([#6]-[#6])[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6](\c2ccccc2)-c2ccccc2)-[#8]-[#6]1=O
Structure:
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