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Target
Baculoviral IAP repeat-containing protein 3 [252-340]
Ligand
BDBM17344
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements.
pH
7.2±n/a
Temperature
295.15±n/a K
Ki
70±n/a nM
Citation
Zobel, K; Wang, L; Varfolomeev, E; Franklin, MC; Elliott, LO; Wallweber, HJ; Okawa, DC; Flygare, JA; Vucic, D; Fairbrother, WJ; Deshayes, K Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 1:525-33 (2006) [PubMed] Article
More Info.:
Target
Name:
Baculoviral IAP repeat-containing protein 3 [252-340]
Synonyms:
API2 | BIRC3 | BIRC3_HUMAN | Inhibitor of apoptosis protein 1-baculovirus IAP repeat 3 (BIR3) chimeric protein | MIHC | RNF49 | cIAP2-BIR3 | cIAP2-BIR3/XIAP-BIR3 chimeric protein | cIAP2XBIR3
Type:
Chimeric Protein
Mol. Mass.:
10368.11
Organism:
Homo sapiens (Human)
Description:
Q13489[252-340]
Residue:
89
Sequence:
MQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPH
Inhibitor
Name:
BDBM17344
Synonyms:
(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanoic acid | AVPW | L-alanyl-L-valyl-L-prolyl-L-tryptophan
Type:
Polypeptide
Emp. Form.:
C24H33N5O5
Mol. Mass.:
471.5493
SMILES:
CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r|