Reaction Details Report a problem with these data
Target
Acid ceramidase
Ligand
BDBM356501
Substrate
n/a
Meas. Tech.
LC-MS Based In Vitro Assay
IC50
75.0±20 nM
Citation
 Piomelli, D; Pizzirani, D; Bach, A; Scarpelli, R; Melzig, L; Mor, M Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments US Patent  US10213416 Publication Date 2/26/2019 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM356501
Synonyms:
6-(4-fluorophenyl)-2-oxo-N-(5- phenylpentyl)-1,3- benzoxazole-3-carboxamide | US10213416, Example 1
Type:
Small organic molecule
Emp. Form.:
C25H23FN2O3
Mol. Mass.:
418.4601
SMILES:
Fc1ccc(cc1)-c1ccc2n(C(=O)NCCCCCc3ccccc3)c(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: