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Target
Acid ceramidase
Ligand
BDBM356503
Substrate
n/a
Meas. Tech.
LC-MS Based In Vitro Assay
IC50
111±30 nM
Citation
 Piomelli, D; Pizzirani, D; Bach, A; Scarpelli, R; Melzig, L; Mor, M Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments US Patent  US10213416 Publication Date 2/26/2019 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM356503
Synonyms:
2-oxo-N-(6-phenylhexyl)-5-[4- (trifluoromethyl) phenyl]-1,3- benzoxazole-3-carboxamide | US10213416, Example 3
Type:
Small organic molecule
Emp. Form.:
C27H25F3N2O3
Mol. Mass.:
482.4942
SMILES:
FC(F)(F)c1ccc(cc1)-c1ccc2oc(=O)n(C(=O)NCCCCCCc3ccccc3)c2c1
Structure:
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