Reaction Details Report a problem with these data
Target
Acid ceramidase
Ligand
BDBM356505
Substrate
n/a
Meas. Tech.
LC-MS Based In Vitro Assay
IC50
26.0±3 nM
Citation
 Piomelli, D; Pizzirani, D; Bach, A; Scarpelli, R; Melzig, L; Mor, M Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments US Patent  US10213416 Publication Date 2/26/2019 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM356505
Synonyms:
6-(4-methoxybenzoyl)-2-oxo- N-(5-phenylpentyl)-1,3- benzoxazole-3-carboxamide | US10213416, Example 6
Type:
Small organic molecule
Emp. Form.:
C27H26N2O5
Mol. Mass.:
458.5057
SMILES:
COc1ccc(cc1)C(=O)c1ccc2n(C(=O)NCCCCCc3ccccc3)c(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: