Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 1
Ligand
BDBM17849
Substrate
BDBM17848
Meas. Tech.
MetAP Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
2900±100 nM
Citation
 Hu, X; Addlagatta, A; Lu, J; Matthews, BW; Liu, JO Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A 103:18148-53 (2006) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM17849
Synonyms:
3-(2,2-dimethylpropanamido)-N-(1,3-thiazol-2-yl)pyridine-2-carboxamide | CHEMBL316308 | pyridine-2-carboxylic acid inhibitor, 2
Type:
Small organic molecule
Emp. Form.:
C14H16N4O2S
Mol. Mass.:
304.367
SMILES:
CC(C)(C)C(=O)Nc1cccnc1C(=O)Nc1nccs1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17848
Synonyms:
1-[(2S)-2-amino-4-(methylsulfanyl)butanoyl]-N-(4-nitrophenyl)pyrrolidine-2-carboxamide | Met-Pro-pNA
Type:
Small organic molecule
Emp. Form.:
C16H22N4O4S
Mol. Mass.:
366.435
SMILES:
CSCC[C@H](N)C(=O)N1CCCC1C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: