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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357496
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
2.00±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357496
Synonyms:
US10214519, Example 240
Type:
Small organic molecule
Emp. Form.:
C24H19ClFN5OS
Mol. Mass.:
479.957
SMILES:
Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)N1CCOCC1)-c1nccs1 |(-4.85,.04,;-3.36,-.35,;-2.81,-1.79,;-1.27,-1.71,;-.18,-2.8,;1.3,-2.4,;1.7,-.91,;.61,.18,;-.87,-.22,;-2.16,.62,;-2.16,2.16,;-.83,2.93,;-.83,4.47,;-2.16,5.24,;-3.5,4.47,;-4.83,5.24,;-4.83,6.78,;-6.17,4.47,;-6.17,2.93,;-4.83,2.16,;-4.83,.62,;-3.5,2.93,;3.19,-.52,;4.28,-1.6,;5.77,-1.21,;6.17,.28,;5.08,1.37,;3.59,.97,;-.58,-4.29,;-2.02,-4.84,;-1.94,-6.38,;-.45,-6.78,;.39,-5.48,)|
Structure:
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