Target
Apelin receptor
Ligand
BDBM269868
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
12.0±n/a nM
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM269868
Synonyms:
(1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-1-(2-hydroxyethoxy)-1-(5-methylpyrimidin-2-yl)propane-2-sulfonamide or (1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-1-(2-hydroxyethoxy)-1-(5-methylpyrimidin-2-yl)propane-2-sulfonamide | US10058550, Example 394.0 | US10221162, Example 395.0 | US9845310, Example 395.0
Type:
Small organic molecule
Emp. Form.:
C26H31N7O6S
Mol. Mass.:
569.633
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,16.17,(1.57,-2.91,;.24,-3.68,;-1.1,-2.91,;-1.14,-1.35,;-2.48,-.58,;-3.81,-1.35,;-3.81,-2.89,;-5.15,-3.66,;-6.48,-2.89,;-2.48,-3.66,;-2.48,-5.2,;-1.23,-6.1,;.1,-5.33,;1.44,-6.1,;.67,-7.43,;2.21,-7.43,;2.77,-5.33,;2.77,-3.79,;4.1,-6.1,;4.1,-7.64,;5.44,-8.41,;5.44,-9.95,;6.77,-10.72,;5.44,-5.33,;6.77,-6.1,;8.1,-5.33,;8.1,-3.79,;9.44,-3.02,;6.77,-3.02,;5.44,-3.79,;-1.71,-7.57,;-3.25,-7.57,;-3.72,-6.1,;-5.21,-5.7,;-5.98,-7.04,;-7.52,-7.04,;-8.29,-5.7,;-7.52,-4.37,;-8.29,-3.04,;-5.98,-4.37,)|
Structure:
Search PDB for entries with ligand similarity: