Reaction Details
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Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM360102
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
13.0±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM360102
Synonyms:
(1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3- | US10221162, Example 398.0
Type:
Small organic molecule
Emp. Form.:
C28H35N7O6S
Mol. Mass.:
597.686
SMILES:
COCCO[C@H]([C@@H](C)S(=O)(=O)N(C)c1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:6.6,5.4,(6.66,-25.04,;6.66,-23.5,;5.32,-22.73,;5.32,-21.19,;3.99,-20.42,;3.99,-18.88,;2.66,-18.11,;2.66,-16.57,;1.32,-18.88,;.55,-20.21,;2.09,-20.21,;-.01,-18.11,;.31,-16.6,;-1.48,-18.58,;-1.93,-20.08,;-3.49,-20.05,;-3.97,-18.58,;-5.43,-18.11,;-6.2,-19.44,;-7.74,-19.44,;-8.51,-18.11,;-7.74,-16.77,;-8.51,-15.44,;-6.2,-16.77,;-2.72,-17.68,;-2.72,-16.14,;-1.34,-15.39,;-.01,-16.16,;1.33,-15.39,;-1.39,-13.83,;-2.72,-13.06,;-4.06,-13.83,;-4.06,-15.37,;-5.39,-16.14,;-6.57,-15.15,;5.32,-18.11,;6.66,-18.88,;7.99,-18.11,;7.99,-16.57,;9.32,-15.8,;6.66,-15.8,;5.32,-16.57,)|
Structure:
