Reaction Details
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Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM360103
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
0.860±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM360103
Synonyms:
(1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3- | US10221162, Example 400.0 | US10221162, Example 401.0 | US10221162, Example 402.0 | US10221162, Example 403.0
Type:
Small organic molecule
Emp. Form.:
C27H33N7O6S
Mol. Mass.:
583.659
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OC[C@@H](C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,18.19,21.23,(-9.31,-4.34,;-10.64,-5.11,;-11.98,-4.34,;-12.02,-2.77,;-13.36,-2,;-14.69,-2.77,;-14.69,-4.31,;-16.02,-5.08,;-17.2,-4.09,;-13.36,-5.08,;-13.36,-6.62,;-12.11,-7.52,;-10.65,-7.05,;-9.31,-7.82,;-10.08,-9.15,;-8.54,-9.15,;-7.98,-7.05,;-7.98,-5.51,;-6.65,-7.82,;-6.65,-9.36,;-5.31,-10.13,;-5.31,-11.67,;-3.98,-12.44,;-6.65,-12.44,;-5.31,-7.05,;-3.98,-7.82,;-2.64,-7.05,;-2.64,-5.51,;-1.31,-4.74,;-3.98,-4.74,;-5.31,-5.51,;-12.59,-8.99,;-14.13,-8.99,;-14.6,-7.52,;-16.07,-7.05,;-16.84,-8.38,;-18.38,-8.38,;-19.15,-7.05,;-18.38,-5.71,;-19.15,-4.38,;-16.84,-5.71,)|
Structure:
