Reaction Details
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Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM360117
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
7.90±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM360117
Synonyms:
(2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-ethyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-(5- | US10221162, Example 418.0 | US9845310, Example 420.0
Type:
Small organic molecule
Emp. Form.:
C24H26FN7O4S
Mol. Mass.:
527.571
SMILES:
CCc1cncc(c1)-c1nnc(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wD:16.17,(-9.66,6.22,;-8.12,6.22,;-7.35,4.88,;-8.12,3.55,;-7.35,2.22,;-5.81,2.22,;-5.04,3.55,;-5.81,4.88,;-3.5,3.55,;-3.02,2.09,;-1.48,2.09,;-1.01,3.55,;.32,4.32,;1.66,3.55,;.32,2.78,;2.99,2.78,;2.99,4.32,;2.99,5.86,;4.33,3.55,;5.66,4.32,;6.99,3.55,;8.33,4.32,;8.33,5.86,;9.66,6.63,;6.99,6.63,;5.66,5.86,;-2.25,4.45,;-2.25,5.99,;-3.59,6.76,;-4.92,5.99,;-6.26,6.76,;-3.59,8.3,;-2.25,9.07,;-.92,8.3,;-.92,6.76,;.41,5.99,;1.75,6.76,)|
Structure:
