Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM360125
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
0.340±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM360125
Synonyms:
(1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3- | US10221162, Example 427.0
Type:
Small organic molecule
Emp. Form.:
C25H30N8O5S
Mol. Mass.:
554.621
SMILES:
CN[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(2.97,14.95,;4.3,15.72,;4.3,17.26,;2.97,18.03,;2.97,19.57,;1.63,17.26,;.86,15.93,;2.4,15.93,;.3,18.03,;-1.04,17.26,;-1.2,15.73,;-2.7,15.41,;-3.47,16.74,;-5.01,16.74,;-5.78,18.08,;-7.32,18.08,;-8.09,16.74,;-7.32,15.41,;-8.09,14.08,;-9.63,14.08,;-5.78,15.41,;-2.44,17.89,;-2.76,19.39,;-4.23,19.87,;-5.72,19.47,;-6.49,20.8,;-4.55,21.38,;-3.4,22.41,;-1.94,21.93,;-1.62,20.42,;-.15,19.95,;1.33,20.35,;5.63,18.03,;6.97,17.26,;8.3,18.03,;8.3,19.57,;9.63,20.34,;6.97,20.34,;5.63,19.57,)|
Structure:
