Reaction Details
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Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM360135
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
52.0±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM360135
Synonyms:
(1R,2R)-1-cyclopropyl-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H- | US10221162, Example 438.0
Type:
Small organic molecule
Emp. Form.:
C27H39N5O6SSi
Mol. Mass.:
589.779
SMILES:
COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@H](O)C2CC2)n1-c1c(OC)cccc1OC |r,wD:22.23,24.25,(-18.17,-10.79,;-16.63,-10.95,;-15.73,-9.71,;-16.36,-8.3,;-15.45,-7.05,;-13.92,-7.21,;-13.29,-8.62,;-14.2,-9.87,;-11.76,-8.78,;-10.99,-10.12,;-9.48,-9.8,;-9.32,-8.26,;-7.99,-7.49,;-7.99,-5.95,;-6.66,-5.18,;-6.66,-3.64,;-5.32,-2.87,;-7.99,-2.87,;-6.66,-2.1,;-6.66,-8.26,;-5.89,-6.93,;-7.43,-9.6,;-5.32,-9.03,;-5.32,-10.57,;-3.99,-8.26,;-3.99,-6.72,;-2.66,-9.03,;-1.89,-10.37,;-1.12,-9.03,;-10.73,-7.64,;-11.05,-6.13,;-12.52,-5.66,;-13.66,-6.69,;-15.12,-6.21,;-12.84,-4.15,;-11.69,-3.12,;-10.23,-3.59,;-9.91,-5.1,;-8.44,-5.58,;-7.3,-4.55,)|
Structure:
