Reaction Details
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Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM269906
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
49.0±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM269906
Synonyms:
(1R,2S)-1-cyclopropyl-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-hydroxy-2-propanesulfonamide or (1S,2R)-1-cyclopropyl-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-hydroxy-2-propanesulfonamide | US10058550, Example 439.0 | US10058550, Example 440.0 | US10221162, Example 440.0 | US9845310, Example 440.0
Type:
Small organic molecule
Emp. Form.:
C22H27N5O6S
Mol. Mass.:
489.545
SMILES:
COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C2CC2)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.41,-8.33,;-6.92,-8.73,;-5.83,-7.64,;-6.23,-6.16,;-5.14,-5.07,;-3.65,-5.47,;-3.25,-6.95,;-4.34,-8.04,;-1.77,-7.35,;-1.29,-8.82,;.25,-8.82,;.73,-7.35,;2.06,-6.58,;3.39,-7.35,;2.62,-8.69,;4.16,-8.69,;4.73,-6.58,;4.73,-5.04,;6.06,-7.35,;6.06,-8.89,;7.39,-6.58,;8.93,-6.58,;8.16,-5.25,;-.52,-6.45,;-.52,-4.91,;-1.85,-4.14,;-3.19,-4.91,;-4.52,-4.14,;-1.85,-2.6,;-.52,-1.83,;.81,-2.6,;.81,-4.14,;2.15,-4.91,;3.48,-4.14,)|
Structure:
