Reaction Details
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Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM360138
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
1.20±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM360138
Synonyms:
(1R,2R)-1-cyclohexyl-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H- | US10221162, Example 441.0
Type:
Small organic molecule
Emp. Form.:
C30H45N5O6SSi
Mol. Mass.:
631.859
SMILES:
COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@H](O)C2CCCCC2)n1-c1c(OC)cccc1OC |r,wD:22.23,24.25,(-19.42,-10.59,;-17.88,-10.76,;-16.98,-9.51,;-17.6,-8.1,;-16.7,-6.86,;-15.17,-7.02,;-14.54,-8.42,;-15.45,-9.67,;-13.01,-8.59,;-12.24,-9.92,;-10.73,-9.6,;-10.57,-8.07,;-9.24,-7.3,;-9.24,-5.76,;-7.91,-4.99,;-7.91,-3.45,;-6.57,-2.68,;-9.24,-2.68,;-7.91,-1.91,;-7.91,-8.07,;-7.14,-6.73,;-8.68,-9.4,;-6.57,-8.84,;-6.57,-10.38,;-5.24,-8.07,;-5.24,-6.53,;-3.9,-8.84,;-3.9,-10.38,;-2.57,-11.15,;-1.24,-10.38,;-1.24,-8.84,;-2.57,-8.07,;-11.98,-7.44,;-12.3,-5.94,;-13.76,-5.46,;-14.91,-6.49,;-16.37,-6.01,;-14.08,-3.95,;-12.94,-2.92,;-11.48,-3.4,;-11.16,-4.9,;-9.69,-5.38,;-8.55,-4.35,)|
Structure:
