Reaction Details
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Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM360141
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
80.0±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM360141
Synonyms:
(1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3- | US10221162, Example 444.0
Type:
Small organic molecule
Emp. Form.:
C29H43N5O7SSi
Mol. Mass.:
633.832
SMILES:
COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@H](O)C2CCOCC2)n1-c1c(OC)cccc1OC |r,wD:24.25,22.23,(-19.49,-10.37,;-17.96,-10.53,;-17.06,-9.29,;-17.68,-7.88,;-16.78,-6.63,;-15.25,-6.79,;-14.62,-8.2,;-15.53,-9.45,;-13.09,-8.36,;-12.32,-9.7,;-10.81,-9.38,;-10.65,-7.84,;-9.32,-7.07,;-9.32,-5.53,;-7.98,-4.76,;-7.98,-3.22,;-6.65,-2.45,;-9.32,-2.45,;-7.98,-1.68,;-7.98,-7.84,;-7.21,-6.51,;-8.75,-9.18,;-6.65,-8.61,;-6.65,-10.15,;-5.32,-7.84,;-5.32,-6.3,;-3.98,-8.61,;-3.98,-10.15,;-2.65,-10.92,;-1.32,-10.15,;-1.32,-8.61,;-2.65,-7.84,;-12.06,-7.22,;-12.38,-5.71,;-13.84,-5.24,;-14.99,-6.27,;-16.45,-5.79,;-14.16,-3.73,;-13.02,-2.7,;-11.55,-3.17,;-11.23,-4.68,;-9.77,-5.16,;-8.62,-4.13,)|
Structure:
