Reaction Details
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Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM269913
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
14.0±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM269913
Synonyms:
(1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)-2-propanesulfonamide or (1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)-2-propanesulfonamide | US10058550, Example 446.0 | US10058550, Example 448.0 | US10221162, Example 448.0 | US9845310, Example 448.0
Type:
Small organic molecule
Emp. Form.:
C24H31N5O7S
Mol. Mass.:
533.597
SMILES:
COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](O)C2CCOCC2)n1-c1c(OC)cccc1OC |r,wU:18.19,wD:16.17,(-8.89,-8.11,;-7.41,-8.51,;-6.32,-7.42,;-6.71,-5.94,;-5.63,-4.85,;-4.14,-5.25,;-3.74,-6.73,;-4.83,-7.82,;-2.25,-7.13,;-1.78,-8.6,;-.24,-8.6,;.24,-7.13,;1.57,-6.36,;2.91,-7.13,;3.68,-8.47,;2.14,-8.47,;4.24,-6.36,;4.24,-4.82,;5.57,-7.13,;5.57,-8.67,;6.91,-6.36,;8.24,-7.13,;9.58,-6.36,;9.58,-4.82,;8.24,-4.05,;6.91,-4.82,;-1.01,-6.23,;-1.01,-4.69,;-2.34,-3.92,;-3.67,-4.69,;-5.01,-3.92,;-2.34,-2.38,;-1.01,-1.61,;.33,-2.38,;.33,-3.92,;1.66,-4.69,;2.99,-3.92,)|
Structure:
