Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM360632
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
7.60±n/a nM
Citation
 Cecere, G; Galley, G; Norcross, R; Patiny-Adam, A; Pflieger, P Substituted pyrazino[2,2-a]isoquinoline derivatives US Patent  US9828374 Publication Date 11/28/2017 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_MOUSE | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Protein
Mol. Mass.:
37635.41
Organism:
Mus musculus (Mouse)
Description:
Q923Y8
Residue:
332
Sequence:
MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM360632
Synonyms:
N4-[(11bR)-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinolin-9-yl]-N6,N6-dimethyl-2-(trifluoromethyl)pyrimidine-4,6-diamine | US9828374, Example 19
Type:
Small organic molecule
Emp. Form.:
C19H23F3N6
Mol. Mass.:
392.4213
SMILES:
CN(C)c1cc(Nc2ccc3[C@@H]4CNCCN4CCc3c2)nc(n1)C(F)(F)F |r|
Structure:
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