Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM360649
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
10.1±n/a nM
Citation
 Cecere, G; Galley, G; Norcross, R; Patiny-Adam, A; Pflieger, P Substituted pyrazino[2,2-a]isoquinoline derivatives US Patent  US9828374 Publication Date 11/28/2017 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM360649
Synonyms:
(R)-1-(2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinolin-9-yl)-3-(4-methoxyphenyl)urea | US9828374, Example 36
Type:
Small organic molecule
Emp. Form.:
C20H24N4O2
Mol. Mass.:
352.4302
SMILES:
COc1ccc(NC(=O)Nc2ccc3[C@@H]4CNCCN4CCc3c2)cc1 |r|
Structure:
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