Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase type 2
Ligand
BDBM361209
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAYS
IC50
0.075±n/a nM
Citation
 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Metallo-beta-lactamase inhibitors US Patent  US10221163 Publication Date 3/5/2019 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
B2 metallo-beta-lactamase | BLA-IMP | BLAB_SERMA | Beta-lactamase type II | IMP-1 | Metallo-beta-lactamase type II
Type:
undefined
Mol. Mass.:
27125.88
Organism:
Serratia marcescens
Description:
P52699
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM361209
Synonyms:
(S)-4-(2-aminobenzo[d]thiazol-4-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide | US10221163, Example 366 | US10544130, Example 366
Type:
Small organic molecule
Emp. Form.:
C19H22N10O4S3
Mol. Mass.:
550.638
SMILES:
Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@]1(N)CCNC1 |r|
Structure:
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