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Target
Apoptosis regulator Bcl-2
Ligand
BDBM361591
Substrate
n/a
Meas. Tech.
Bcl-2 and Bcl-xL Inhibition
IC50
2.40±n/a nM
Citation
 Wang, S; Chen, J N-(phenylsulfonyl)benzamides and related compounds as BCL-2 inhibitors US Patent  US10221174 Publication Date 3/5/2019 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM361591
Synonyms:
2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4- ((6-(4-chlorophenyl)spiro[3.5]non-6-en-7- yl)methyl)piperazin-1-yl)-N-((4-nitro-1- (tetrahydro-2H-pyran-4-yl)-3a,7a-dihydro- 1H-indazol-6-yl)sulfonyl)benzamide | US10221174, Compound 64 | US10829488, Compound 64 | US11718613, Compound 64
Type:
Small organic molecule
Emp. Form.:
C46H47ClN8O7S
Mol. Mass.:
891.433
SMILES:
[O-][N+](=O)c1cc(cc2n(ncc12)C1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1 |t:51|
Structure:
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