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Target
C-X-C chemokine receptor type 2
Ligand
BDBM150811
Substrate
n/a
Meas. Tech.
FLIPR-3 Calcium Assay
IC50
38.0±3 nM
Citation
 Maeda, DY; Zebala, JA Pyridinecarboxamides as CXCR2 modulators US Patent  USRE47267 Publication Date 3/5/2019 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM150811
Synonyms:
US8981106, 1 (SX-517) | USRE47267, Compound 1
Type:
Small organic molecule
Emp. Form.:
C19H16BFN2O3S
Mol. Mass.:
382.216
SMILES:
OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Structure:
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