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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM362673
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<25±n/a nM
Citation
 Combs, AP; Sparks, RB Tricyclic heterocycles as bet protein inhibitors US Patent  US9834565 Publication Date 12/5/2017 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM362673
Synonyms:
(4S)-2-[4-(cyclobutylcarbonyl)piperazin-1- yl]-7-(3,5-dimethylisoxazol-4-yl)-4- pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazine | US10227359, Example 28 | US10618910, Example 28 | US9834565, Example 28
Type:
Small organic molecule
Emp. Form.:
C28H30N6O3
Mol. Mass.:
498.5762
SMILES:
Cc1noc(C)c1-c1ccc2nc(N3CCN(CC3)C(=O)C3CCC3)n3[C@H](COc1c23)c1ccccn1 |wD:26.36,(.39,-5.61,;1.85,-6.08,;2.33,-7.55,;3.87,-7.55,;4.34,-6.08,;5.81,-5.61,;3.1,-5.18,;3.1,-3.64,;4.43,-2.87,;4.43,-1.33,;3.1,-.56,;2.53,.88,;.99,.88,;.22,2.21,;-1.32,2.21,;-2.09,3.55,;-1.32,4.88,;.22,4.88,;.99,3.55,;-2.09,6.21,;-1.32,7.55,;-3.63,6.21,;-4.72,5.12,;-5.81,6.21,;-4.72,7.3,;.43,-.56,;-.9,-1.33,;-.9,-2.87,;.43,-3.64,;1.76,-2.87,;1.76,-1.33,;-2.24,-.56,;-3.57,-1.33,;-4.91,-.56,;-4.91,.98,;-3.57,1.75,;-2.24,.98,)|
Structure:
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