Target

Ligand

Substrate

Meas. Tech.

Enzyme Inhibition Assay

pH

5.5000±n/a

Temperature

295.1500±n/a K

Citation

 Altmann, E; Aichholz, R; Betschart, C; Buhl, T; Green, J; Irie, O; Teno, N; Lattmann, R; Tintelnot-Blomley, M; Missbach, M 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem 50:591-4 (2007) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Procathepsin L

Synonyms:

Cathepsin L1 | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein | CTSL CTSL1 | CATL1_HUMAN | CTSL | CTSL1

Type:

Enzyme

Mol. Mass.:

37557.19

Organism:

Human

Description:

Purchased from Calbiochem (San Diego, CA).

Residue:

333

Sequence:

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM19733

Synonyms:

2-cyano-4-(cyclohexylamino)-N-[2-(3-methoxyphenyl)ethyl]pyrimidine-5-carboxamide | 2-Cyano-pyrimidine, 16c

Type:

Small organic molecule

Emp. Form.:

C21H25N5O2

Mol. Mass.:

379.20

SMILES:

COc1cccc(CCNC(=O)c2cnc(nc2NC2CCCCC2)C#N)c1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM19485

Synonyms:

Fluorogenic substrate | Z-Phe-Arg-AMC.HCl | Cbz-Phe-Arg-AMC

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: