Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM270203
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding
EC50
2.00±n/a nM
Citation
Chen, N; Chen, X; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Wang, X; Yang, K; Debenedetto, MV; Hedley, SJ Intermediates for preparing triazole agonists of the APJ receptor US Patent US9845310 Publication Date 12/19/2017
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM270203
Synonyms:
(1R,2S,P)N-(4-(2,4-dimethoxy-3-pyridinyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-methoxy-1-(5-methyl-2-pyrimidinyl)-2-propanesulfonamide and (1R,2S,M)-N-(4-(2,4-dimethoxy-3-pyridinyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-y0-1-methoxy-1-(5-methyl-2-pyrimidinyl)-2-propanesulfonamide | US10058550, Example 771.0 | US10058550, Example 772.0 | US10221162, Example 772.0 | US9845310, Example 636.0
Type:
Small organic molecule
Emp. Form.:
C24H28N8O6S
Mol. Mass.:
556.594
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(7.76,-2.26,;6.22,-2.26,;5.45,-.93,;3.91,-.93,;3.14,.41,;3.14,-2.26,;4.48,-3.03,;2.37,-3.59,;1.81,-1.49,;.48,-2.26,;.48,-3.8,;-.99,-4.27,;-1.89,-3.03,;-3.38,-2.63,;-3.78,-1.14,;-5.27,-.74,;-6.36,-1.83,;-5.96,-3.32,;-7.05,-4.41,;-8.53,-4.01,;-4.47,-3.72,;-.99,-1.78,;-1.53,.33,;-.44,1.42,;1.05,1.02,;2.14,2.11,;-.84,2.9,;-2.32,3.3,;-3.41,2.21,;-3.02,.73,;-4.1,-.36,;-5.59,.04,;6.22,.41,;7.76,.41,;8.53,1.74,;7.76,3.08,;8.53,4.41,;6.22,3.08,;5.45,1.74,)|