Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM143768
Substrate
n/a
Meas. Tech.
Receptor Radioligand Binding Assay
Ki
>10000±n/a nM
Citation
 Gelin, CF; Lebold, TP; Shireman, BT Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US9845333 Publication Date 12/19/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
Hcrtr2 | Hypocretin receptor type 2 | OX2R_RAT | Orexin receptor 2 | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Ox-2-R | Ox2-R | Ox2R
Type:
Protein
Mol. Mass.:
52508.46
Organism:
Rattus norvegicus (Rat)
Description:
P56719
Residue:
460
Sequence:
MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
  
Inhibitor
Name:
BDBM143768
Synonyms:
US10183953, Example 29 | US8969352, 29 | US9611277, Example 29 | US9845333, 29
Type:
Small organic molecule
Emp. Form.:
C21H19F3N6O2
Mol. Mass.:
444.4098
SMILES:
Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 |TLB:12:11:7.8:24,5:7:11.10:24|
Structure:
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