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Target
Rho-associated protein kinase 1 [17-535]
Ligand
BDBM362931
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>10000000±n/a nM
Citation
 Glick, GD 1,4-benzodiazepone-2,5-diones and related compounds with therapeutic properties US Patent  US9849138 Publication Date 12/26/2017 
Target
Name:
Rho-associated protein kinase 1 [17-535]
Synonyms:
ROCK1 | ROCK1_HUMAN | Rho GDP-dissociation inhibitor 1 | Rho Kinase 1 | Rho-associated protein kinase 1 (ROCK1)
Type:
Protien
Mol. Mass.:
60345.48
Organism:
Homo Sapiens (Human)
Description:
aa 17-535
Residue:
519
Sequence:
LLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
  
Inhibitor
Name:
BDBM362931
Synonyms:
US9849138, 5
Type:
Small organic molecule
Emp. Form.:
C22H18ClN3O2
Mol. Mass.:
391.85
SMILES:
CN1c2c(Cl)cccc2C(=O)NC(Cc2ccc(cc2)-c2ccncc2)C1=O
Structure:
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