Target

Ligand

Substrate

Meas. Tech.

Enzyme Inhibition Assay and Whole Cell Enzyme Occupancy Assay

pH

5.5000±n/a

Temperature

295.1500±n/a K

Citation

 Falgueyret, JP; Desmarais, S; Oballa, R; Black, WC; Cromlish, W; Khougaz, K; Lamontagne, S; Massé, F; Riendeau, D; Toulmond, S; Percival, MD Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J Med Chem 48:7535-43 (2005) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Procathepsin L

Synonyms:

Cathepsin L1 | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein | CTSL CTSL1 | CATL1_HUMAN | CTSL | CTSL1

Type:

Enzyme

Mol. Mass.:

37557.19

Organism:

Human

Description:

Purchased from Calbiochem (San Diego, CA).

Residue:

333

Sequence:

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM19855

Synonyms:

N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl) | CHEMBL371064 | basic piperazine-containing compound, 10 | N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-(4-propylpiperazin-1-yl)benzamide | Balicatib

Type:

Small organic molecule

Emp. Form.:

C23H33N5O2

Mol. Mass.:

411.26

SMILES:

CCCN1CCN(CC1)c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM19480

Synonyms:

Fluorogenic substrate | Z-Leu-Arg-AMC | Cbz-Leu-Arg-AMC

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: