Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM363474
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
IC50
6.40±n/a nM
Citation
 Pasternak, A; Ding, F; Dong, S; Jiang, J; Tang, H; Gu, X; DeJesus, RK; Frie, J; Fu, Q; Suzuki, T; Pu, Z Inhibitors of the renal outer medullary potassium channel US Patent  US9850245 Publication Date 12/26/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM363474
Synonyms:
(R)-9-(2-hydroxy-2-(4-methyl-1- oxo-1,3-dihydroisobenzofuran-5- yl)ethyl)-4-(4-methyl-5-oxo-2,5- dihydrofuran-3-yl)-1-oxa-4,9- diazaspiro[5.5]undecan-5-one | US9850245, Example 8A
Type:
Small organic molecule
Emp. Form.:
C24H28N2O7
Mol. Mass.:
456.4883
SMILES:
CC1=C(COC1=O)N1CCOC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Structure:
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